Epstein-BARR virus-associated lymphoproliferative disorder after unrelated bone marrow transplantation in a young child with Wiskott-Aldrich syndrome

Yoji Sasahara, Shin Kawai, Masayuki Itano, Satoru Kumaki, Hiromi Fujie, Masayoshi Minegishi, Shigeru Tsuchiya, Tasuke Konno

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

We report a case of a 16-month-old Wiskott-Aldrich syndrome (WAS) patient with a WASP gene mutation who received human leukocyte antigen (HLA)- matched, unrelated allogeneic bone marrow transplantation (BMT) followed by an Epstein-Barr virus-associated lymphoproliferative disorder (EB-LPD), diagnosed by clinical findings, polymerase chain reaction detection of the EB virus genome, and spontaneous lymphocyte proliferation of donor cell origin. EB-LPD is one of frequent lethal complications in HLA-mismatched or unrelated BMT in this syndrome. Adoptive immunotherapy with donor leukocyte transfusion, including appropriate numbers of CD3-positive T cells, was effective for the EB-LPD, achieving almost complete recovery I year later without any findings of graft-versus-host disease.

Original languageEnglish
Pages (from-to)347-352
Number of pages6
JournalPediatric Hematology and Oncology
Volume15
Issue number4
DOIs
Publication statusPublished - 1998

Keywords

  • Donor leukocyte transfusion
  • Epstein-Barr virus-associated lymphoproliferative disorder
  • Unrelated bone marrow transplantation
  • Wiskott- Aldrich syndrome

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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