Epstein-Barr virus-associated Hodgkin's disease in a patient with Wiskott-Aldrich syndrome

Y. Sasahara, H. Fujie, S. Kumaki, Y. Ohashi, M. Minegishi, S. Tsuchiya, S. L. Johnston

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

Wiskott-Aldrich syndrome is a primary immunodeficiency syndrome in which the majority of malignant complications are non-Hodgkin's lymphoma. We report here a Wiskott-Aldrich syndrome patient who developed Epstein-Barr virus-positive Hodgkin's disease in the bilateral pulmonary hilar lymph nodes. The treatment was successful as the patient achieved a complete response and event-free survival for more than 4 y. Conclusion: This case is very rare, but highly suggestive of the immune-mediated mechanisms in the pathogenesis of Epstein-Barr virus-associated Hodgkin's disease in an immunodeficiency patient.

Original languageEnglish
Pages (from-to)1348-1351
Number of pages4
JournalActa Paediatrica, International Journal of Paediatrics
Volume90
Issue number11
DOIs
Publication statusPublished - 2001

Keywords

  • Epstein-Barr virus
  • Hodgkin's disease
  • Latent membrane protein-1
  • Wiskott-Aldrich syndrome

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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