TY - JOUR
T1 - Epstein-Barr virus associated Hodgkin lymphoma in a 9-year-old girl receiving long-term methotrexate therapy for juvenile idiopathic arthritis
AU - Takeyama, Junji
AU - Sato, Atsushi
AU - Nakano, Kyoko
AU - Abukawa, Daiki
AU - Ichinohazama, Ryo
AU - Imaizumi, Masue
PY - 2006/9
Y1 - 2006/9
N2 - We describe a case of Hodgkin lymphoma developing in a 9-year-old girl with polyarticular, rheumatoid factor-positive juvenile idiopathic arthritis treated with methotrexate (MTX), prednisone, and naproxen for 5 years. Pathologic and molecular analyses revealed that the Hodgkin cells contained Epstein-Barr virus and the viral DNA was monoclonal. She achieved complete remission after MTX withdrawal, chemotherapy, and radiation. To the best of my knowledge, this is the sixth report of Hodgkin lymphoma in patients with juvenile idiopathic arthritis receiving low dose MTX therapy.
AB - We describe a case of Hodgkin lymphoma developing in a 9-year-old girl with polyarticular, rheumatoid factor-positive juvenile idiopathic arthritis treated with methotrexate (MTX), prednisone, and naproxen for 5 years. Pathologic and molecular analyses revealed that the Hodgkin cells contained Epstein-Barr virus and the viral DNA was monoclonal. She achieved complete remission after MTX withdrawal, chemotherapy, and radiation. To the best of my knowledge, this is the sixth report of Hodgkin lymphoma in patients with juvenile idiopathic arthritis receiving low dose MTX therapy.
KW - Epstein-Barr virus
KW - Hodgkin lymphoma
KW - Juvenile idiopathic arthritis
KW - Methotrexate
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U2 - 10.1097/01.mph.0000212960.66221.e7
DO - 10.1097/01.mph.0000212960.66221.e7
M3 - Article
C2 - 17006270
AN - SCOPUS:33749316405
VL - 28
SP - 622
EP - 624
JO - Journal of Pediatric Hematology/Oncology
JF - Journal of Pediatric Hematology/Oncology
SN - 1077-4114
IS - 9
ER -