Epstein-Barr virus associated Hodgkin lymphoma in a 9-year-old girl receiving long-term methotrexate therapy for juvenile idiopathic arthritis

Junji Takeyama, Atsushi Sato, Kyoko Nakano, Daiki Abukawa, Ryo Ichinohazama, Masue Imaizumi

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

We describe a case of Hodgkin lymphoma developing in a 9-year-old girl with polyarticular, rheumatoid factor-positive juvenile idiopathic arthritis treated with methotrexate (MTX), prednisone, and naproxen for 5 years. Pathologic and molecular analyses revealed that the Hodgkin cells contained Epstein-Barr virus and the viral DNA was monoclonal. She achieved complete remission after MTX withdrawal, chemotherapy, and radiation. To the best of my knowledge, this is the sixth report of Hodgkin lymphoma in patients with juvenile idiopathic arthritis receiving low dose MTX therapy.

Original languageEnglish
Pages (from-to)622-624
Number of pages3
JournalJournal of Pediatric Hematology/Oncology
Volume28
Issue number9
DOIs
Publication statusPublished - 2006 Sep

Keywords

  • Epstein-Barr virus
  • Hodgkin lymphoma
  • Juvenile idiopathic arthritis
  • Methotrexate

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

Fingerprint Dive into the research topics of 'Epstein-Barr virus associated Hodgkin lymphoma in a 9-year-old girl receiving long-term methotrexate therapy for juvenile idiopathic arthritis'. Together they form a unique fingerprint.

Cite this