EPR spin-trapping study of nitric oxide formation during bilateral carotid occlusion in the rat

Shinya Sato, Teiji Tominaga, Tomoko Ohnishi, S. Tsuyoshi Ohnishi

Research output: Contribution to journalArticlepeer-review

63 Citations (Scopus)

Abstract

The formation of nitric oxide (NO) radicals was demonstrated by electron paramagnetic resonance spectroscopy in the rat during varying degrees of brain ischemia. Diethyldithiocarbamate and Fe-citrate were used as in vivo spin-trapping reagents. The signal of NO spin adducts increased in accordance with the degree of ischemic insults. The formation of NO radicals was inhibited by NG-nitro]l-arginine methyl ester.

Original languageEnglish
Pages (from-to)195-197
Number of pages3
JournalBBA - Molecular Basis of Disease
Volume1181
Issue number2
DOIs
Publication statusPublished - 1993 Apr 30
Externally publishedYes

Keywords

  • Brian ischemia
  • Common carotid occlusion
  • EPR
  • Nitric oxide (NO)
  • Spin-trapping

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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