TY - JOUR
T1 - Epithelioid leiomyosarcoma of the uterine cervix
T2 - A case report and review of the literature
AU - Toyoshima, Masafumi
AU - Okamura, Chikako
AU - Niikura, Hitoshi
AU - Ito, Kiyoshi
AU - Yaegashi, Nobuo
PY - 2005/6
Y1 - 2005/6
N2 - Background. Epithelioid leiomyosarcomas arising from the uterine cervix are extremely rare neoplasms, with only three cases reported in the English literature. Case. A 53-year-old Japanese woman was admitted to our university hospital due to massive vaginal bleeding from a cervical tumor. A total hysterectomy with bilateral salpingo-oophorectomy was performed. Histological findings, including immunohistochemical study using desmin, SMA, cytokeratin, S-100, HMB-45, vimentin, melan-A, and CD68, led to a diagnosis of epithelioid leiomyosarcoma of the uterine cervix. The patient underwent adjuvant chemotherapy and has been disease-free for over 20 months. Conclusion. Immunohistochemical studies may be needed to differentiate among the alternative diagnoses of malignant melanoma, metastatic carcinoma, and epithelioid sarcoma. Additional cases are needed to develop optimal management strategies and to predict prognosis.
AB - Background. Epithelioid leiomyosarcomas arising from the uterine cervix are extremely rare neoplasms, with only three cases reported in the English literature. Case. A 53-year-old Japanese woman was admitted to our university hospital due to massive vaginal bleeding from a cervical tumor. A total hysterectomy with bilateral salpingo-oophorectomy was performed. Histological findings, including immunohistochemical study using desmin, SMA, cytokeratin, S-100, HMB-45, vimentin, melan-A, and CD68, led to a diagnosis of epithelioid leiomyosarcoma of the uterine cervix. The patient underwent adjuvant chemotherapy and has been disease-free for over 20 months. Conclusion. Immunohistochemical studies may be needed to differentiate among the alternative diagnoses of malignant melanoma, metastatic carcinoma, and epithelioid sarcoma. Additional cases are needed to develop optimal management strategies and to predict prognosis.
KW - Case report
KW - Cervical leiomyosarcoma
KW - Epithelioid leiomyosarcoma
KW - Immunohistochemistry
KW - Uterine cervix
UR - http://www.scopus.com/inward/record.url?scp=20444498135&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=20444498135&partnerID=8YFLogxK
U2 - 10.1016/j.ygyno.2005.02.028
DO - 10.1016/j.ygyno.2005.02.028
M3 - Article
C2 - 15890394
AN - SCOPUS:20444498135
SN - 0090-8258
VL - 97
SP - 957
EP - 960
JO - Gynecologic Oncology
JF - Gynecologic Oncology
IS - 3
ER -