Epithelial cell division: Aurora kicks Lgl to the cytoplasmic curb

Yu Ichiro Nakajima, Matthew C. Gibson

Research output: Contribution to journalShort surveypeer-review

5 Citations (Scopus)

Abstract

The Drosophila neoplastic tumor suppressor Lethal giant larvae (Lgl) regulates apico-basal polarity in epithelia as well as the asymmetric segregation of cell fate in neural progenitors. Two new studies uncover a new facet of its regulation in epithelia, where Aurora-dependent phosphorylation triggers Lgl dissociation from the basolateral cortex to facilitate planar orientation of the mitotic spindle.

Original languageEnglish
Pages (from-to)R43-R45
JournalCurrent Biology
Volume25
Issue number1
DOIs
Publication statusPublished - 2015 Jan 5
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Fingerprint Dive into the research topics of 'Epithelial cell division: Aurora kicks Lgl to the cytoplasmic curb'. Together they form a unique fingerprint.

Cite this