Epigenetic stimulation of polyketide production in Chaetomium cancroideum by an NAD+-dependent HDAC inhibitor

Teigo Asai, Shuntaro Morita, Tohru Taniguchi, Kenji Monde, Yoshiteru Oshima

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

Exposure of the fungus Chaetomium cancroideum to an NAD+-dependent HDAC inhibitor, nicotinamide, enhanced the production of aromatic and branched aliphatic polyketides, which allowed us to isolate new secondary metabolites, chaetophenol G and cancrolides A and B. Their structures were determined using spectroscopic analyses, and their absolute configuration was elucidated by electronic circular dichroism (ECD), vibrational circular dichroism (VCD), and chemical transformations. Biosynthesis of the branched aliphatic polyketide skeletons in cancrolides A and B was evidenced by conducting a feeding experiment using compounds labeled with a 13C stable isotope.

Original languageEnglish
Pages (from-to)646-651
Number of pages6
JournalOrganic and Biomolecular Chemistry
Volume14
Issue number2
DOIs
Publication statusPublished - 2016 Jan 1

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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