Epigenetic regulation for the induction of meiosis

Y. Matsui, K. Hayashi

Research output: Contribution to journalShort surveypeer-review

16 Citations (Scopus)


The germ cell lineage is the sole cell lineage through which genomic information is transmitted into successive generations. To this end, germ cells undergo various specific differentiation steps including meiosis, whose regulation seems to correlate closely with fundamental mechanisms that create differences between germ cells and somatic cells. In mammals, meiosis is triggered by extra-embryonic stimuli such as retinoic acid, which may induce various intracellular molecular cascades promoting meiosis. In addition, the specific epigenetic status arranged in germ cells before and after induction of meiosis, including meiosis-specific transcription control based on histone methylation by a novel histone methyltransferase Meisetz, is also critical for its proper progression.

Original languageEnglish
Pages (from-to)257-262
Number of pages6
JournalCellular and Molecular Life Sciences
Issue number3
Publication statusPublished - 2007 Feb


  • Chromatin
  • Chromosome
  • DNA methylation
  • Germ cell
  • Histone methylation
  • Meiosis
  • Methyltransferase
  • Retinoic acid

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology


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