Ephrin-A1 promotes the malignant progression of intestinal tumors in Apcmin/+ mice

L. Shi, F. Itoh, S. Itoh, S. Takahashi, M. Yamamoto, M. Kato

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

The ephrin-A1 and EphA receptors are frequently highly expressed in different human cancers, suggesting that they may promote tumor development and progression. We generated transgenic mice carrying Fabpl4xat-132 ephrin-A1, which express ephrin-A1 in the intestinal epithelial cells. Those mice were then mated with Apcmin/+ mice to produce the compound mice, which overexpress ephrin-A1 in the intestinal tumors of Apcmin/+ mice. We compared the number, size and histopathological features of the intestinal tumors in the Fabpl4xat-132 ephrin-A1/Apcmin/+ compound mice with those of the Apcmin/+ mice. The compound mice showed an increased number of intestinal tumors, significantly in the large intestine, and developed more invasive tumors. Among the 20 mice of each type examined, 5 Apcmin/+ mice developed 5 invasive tumors, 1 invasive tumor in each mouse, in the proximal or middle portions of the small intestine. On the other hand, 14 out of 20 compound mice developed 29 invasive tumors and 16 of them were in the distal small intestine and the large intestine, where transgenic ephrin-A1 was highly expressed. These results suggested that the increased expression of ephrin-A1 accelerated the malignant progression of the intestinal adenoma to invasive tumors.

Original languageEnglish
Pages (from-to)3265-3273
Number of pages9
JournalOncogene
Volume27
Issue number23
DOIs
Publication statusPublished - 2008 May 22

Keywords

  • Apc mice
  • Ephrin-A1
  • Intestinal adenoma
  • Invasion

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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