Enzyme transistor circuits for reaction-diffusion computing

Masahiko Hiratsuka, Takafumi Aoki, Tatsuo Higuchi

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


This paper explores the possibility of constructing massively parallel computing systems using molecular electronics technology. By employing specificity of biological molecules, such as enzymes, new integrated circuit architectures which are essentially free from interconnection problems could be constructed. To clarify the proposed concept, this paper presents a functional model of a basic biomolecular switching device called an enzyme transistor. The enzyme transistor is, in a sense, an artificial catalyst which selects a specific substrate molecule and transforms it into a specific product. Using this primitive function, various wire-free computing circuits can be realized. Examples described in this paper include basic analog amplifiers and digital logic circuits. This paper also presents the design of an excitable enzyme transistor circuit and demonstrates the potential of enzyme transistors for creating reaction-diffusion dynamics that performs useful computations in a massively parallel fashion.

Original languageEnglish
Pages (from-to)294-303
Number of pages10
JournalIEEE Transactions on Circuits and Systems I: Fundamental Theory and Applications
Issue number2
Publication statusPublished - 1999


  • Molecular computing
  • Molecular devices
  • Nonlinear signal processing
  • Parallel processing
  • Pattern formation
  • Reaction-diffusion dynamics

ASJC Scopus subject areas

  • Electrical and Electronic Engineering


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