TY - GEN
T1 - Enzyme-responsive micelle-vesicle transition
T2 - 2007 International Symposium on Micro-NanoMechatronics and Human Science, MHS
AU - Akiyoshi, Kazunari
AU - Morimoto, Nobuyuki
AU - Murota, Akifumi
PY - 2007/12/1
Y1 - 2007/12/1
N2 - New enzyme-responsive micellar systems in which an enzymatic reaction controls the amphiphilicity of the surfactants were reported. The surfactants in our study consist of a short alkyl chain and a maltooligomer as a primer which can be synthesized enzymatically. In the presence of phosphorylase and α-D-glucose-1-phosphate (G1P), the elongation reaction of the saccharide chain proceeds from the non-reducing 4-OH terminus of the glucan chain. Amylose-primer surfactants (C12MP) where an alkyl group (C12) is linked to the reduced terminus of maltopentaose form micelles in water, which are dissociated upon the enzymatic elongation reaction of the sugar moiety. The micelle-to-vesicle transition of mixed lipid/ primer systems can be controlled by using this property. This new type of transition system can be used in the reconsititution of transmembrane proteins to liposome.
AB - New enzyme-responsive micellar systems in which an enzymatic reaction controls the amphiphilicity of the surfactants were reported. The surfactants in our study consist of a short alkyl chain and a maltooligomer as a primer which can be synthesized enzymatically. In the presence of phosphorylase and α-D-glucose-1-phosphate (G1P), the elongation reaction of the saccharide chain proceeds from the non-reducing 4-OH terminus of the glucan chain. Amylose-primer surfactants (C12MP) where an alkyl group (C12) is linked to the reduced terminus of maltopentaose form micelles in water, which are dissociated upon the enzymatic elongation reaction of the sugar moiety. The micelle-to-vesicle transition of mixed lipid/ primer systems can be controlled by using this property. This new type of transition system can be used in the reconsititution of transmembrane proteins to liposome.
UR - http://www.scopus.com/inward/record.url?scp=50149092646&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=50149092646&partnerID=8YFLogxK
U2 - 10.1109/MHS.2007.4420832
DO - 10.1109/MHS.2007.4420832
M3 - Conference contribution
AN - SCOPUS:50149092646
SN - 9781424418589
T3 - 2007 International Symposium on Micro-NanoMechatronics and Human Science, MHS
SP - 91
EP - 95
BT - 2007 International Symposium on Micro-NanoMechatronics and Human Science, MHS
Y2 - 11 November 2007 through 14 November 2007
ER -