Enzymatic preparation of hollow yttrium oxide microspheres for in situ radiotherapy of deep-seated cancer

Masakazu Kawashita, Yoshihisa Takayama, Tadashi Kokubo, Gikan H. Takaoka, Norio Araki, Masahiro Hiraoka

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

Chemically durable microspheres 20-30 μm in diameter containing a large amount of yttrium are useful for in situ radiotherapy of cancer, as they can be activated by neutron bombardment to form β-emitters, and can be injected into the vicinity of the cancer cells to impart a large localized dose of β-radiation. In this study, preparation of hollow Y 2O 3 microspheres using an enzymatic reaction was attempted, and the structure and chemical durability of the resulting microspheres were investigated. Hollow Y 2O 3 microspheres 20-30 μm in diameter were successfully prepared by this enzymatic method. The outer surface of the microspheres was smooth and dense, and the inner parts had a honeycombed structure. In simulated body fluids at pH 6 and 7, the hollow Y 2O 3 microspheres showed high chemical durability.

Original languageEnglish
Pages (from-to)1347-1351
Number of pages5
JournalJournal of the American Ceramic Society
Volume89
Issue number4
DOIs
Publication statusPublished - 2006 Apr
Externally publishedYes

ASJC Scopus subject areas

  • Ceramics and Composites
  • Materials Chemistry

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