Enzymatic diagnosis of nonketotic hyperglycinemia with lymphoblasts

Shigeo Kure; Kunlaki Narisawa; Keiya Tada

doi:10.1016/S0022-3476(05)80610-9

Enzymatic diagnosis of nonketotic hyperglycinemia with lymphoblasts

Shigeo Kure, Kunlaki Narisawa, Keiya Tada

MED - Medical Sciences

Research output: Contribution to journal › Article

41 Citations (Scopus)

Abstract

We developed a new enzymatic assay for the glycine cleavage system that used Epstein-Barr virus-transformed lymphoblasts instead of liver biopsy specimens. Patients with nonketotic hyperglycinemia from a deficiency of P-protein could be clearly distinguished from control subjects by activities in their lymphoblasts, suggesting the clinical usefulness of this method.

Original language	English
Pages (from-to)	95-98
Number of pages	4
Journal	The Journal of Pediatrics
Volume	120
Issue number	1
DOIs	https://doi.org/10.1016/S0022-3476(05)80610-9
Publication status	Published - 1992 Jan

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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title = "Enzymatic diagnosis of nonketotic hyperglycinemia with lymphoblasts",

abstract = "We developed a new enzymatic assay for the glycine cleavage system that used Epstein-Barr virus-transformed lymphoblasts instead of liver biopsy specimens. Patients with nonketotic hyperglycinemia from a deficiency of P-protein could be clearly distinguished from control subjects by activities in their lymphoblasts, suggesting the clinical usefulness of this method.",

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AU - Tada, Keiya

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AB - We developed a new enzymatic assay for the glycine cleavage system that used Epstein-Barr virus-transformed lymphoblasts instead of liver biopsy specimens. Patients with nonketotic hyperglycinemia from a deficiency of P-protein could be clearly distinguished from control subjects by activities in their lymphoblasts, suggesting the clinical usefulness of this method.

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