Entorhinal-hippocampal interactions revealed by real-time imaging

Toshio Iijima, Menno P. Witter, Michinori Ichikawa, Takashi Tominaga, Riichi Kajiwara, Gen Matsumoto

    Research output: Contribution to journalArticlepeer-review

    199 Citations (Scopus)

    Abstract

    The entorhinal cortex provides the major cortical input to the hippocampus, and both structures have been implicated in memory processes. The dynamics of neuronal circuits in the entorhinal-hippocampal system were studied in slices by optical imaging with high spatial and temporal resolution. Reverberation of neural activity was detected in the entorhinal cortex and was more prominent when the inhibition due to γ-aminobutyric acid was slightly suppressed. Neural activity was transferred in a frequency-dependent way from the entorhinal cortex to the hippocampus. The entorhinal neuronal circuit could contribute to memory processes by holding information and selectively gating the entry of information into the hippocampus.

    Original languageEnglish
    Pages (from-to)1176-1179
    Number of pages4
    JournalScience
    Volume272
    Issue number5265
    DOIs
    Publication statusPublished - 1996 May 24

    ASJC Scopus subject areas

    • General

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