Enterovirus 68 among children with severe acute respiratory infection, the Philippines

Tadatsugu Imamura, Naoko Fuji, Akira Suzuki, Raita Tamaki, Mariko Saito, Rapunzel Aniceto, Hazel Galang, Lydia Sombrero, Soccoro Lupisan, Hitoshi Oshitani

Research output: Contribution to journalArticlepeer-review

100 Citations (Scopus)

Abstract

Enterovirus 68 (EV68) is a rare enterovirus associated with respiratory illness that, unlike other enteroviruses, has been identified only from respiratory specimens. We identified EV68 from respiratory specimens of children hospitalized with a diagnosis of severe pneumonia in Leyte, Republic of the Philippines. Twenty-one samples showed high similarity with EV68 by sequencing of 5′ nontranslated region; 17 of these samples were confirmed as EV68 by sequencing of viral protein 1 capsid coding region. Most previously reported EV68 cases had been identified as sporadic cases. All 21 patients we identified had severe illness, and 2 died, possibly the first reported fatal cases associated with EV68 infection. Our study suggests that EV68 may be a possible causative agent of severe respiratory illnesses.

Original languageEnglish
Pages (from-to)1430-1435
Number of pages6
JournalEmerging Infectious Diseases
Volume17
Issue number8
DOIs
Publication statusPublished - 2011 Aug

ASJC Scopus subject areas

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases

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