Enhancements in the utilization of antigene oligonucleotides in the nucleus by booster oligonucleotides

Lei Wang; Hidenori Okamura; Shigeki Sasaki; Yosuke Taniguchi

doi:10.1039/d0cc04240d

Enhancements in the utilization of antigene oligonucleotides in the nucleus by booster oligonucleotides

Lei Wang, Hidenori Okamura, Shigeki Sasaki, Yosuke Taniguchi

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

We recently found the translocation of double-stranded DNA into the nucleus. We herein describe the concept of novel booster oligodeoxynucleotides including 2′-deoxy uridine, which release antigene oligonucleotides in the nucleus by enzymatic digestion. This system exhibited stronger hTERT mRNA expression inhibitory activity than single-stranded antigene oligonucleotides.

Original language	English
Pages (from-to)	9731-9734
Number of pages	4
Journal	Chemical Communications
Volume	56
Issue number	67
DOIs	https://doi.org/10.1039/d0cc04240d
Publication status	Published - 2020 Aug 28
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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title = "Enhancements in the utilization of antigene oligonucleotides in the nucleus by booster oligonucleotides",

abstract = "We recently found the translocation of double-stranded DNA into the nucleus. We herein describe the concept of novel booster oligodeoxynucleotides including 2′-deoxy uridine, which release antigene oligonucleotides in the nucleus by enzymatic digestion. This system exhibited stronger hTERT mRNA expression inhibitory activity than single-stranded antigene oligonucleotides.",

author = "Lei Wang and Hidenori Okamura and Shigeki Sasaki and Yosuke Taniguchi",

note = "Funding Information: The present study was supported by Grants-in-Aid for Scientific Research (B) (Grant Number 19H03351 for Y. T. and 18H02558 for S. S.) from the Japan Society for the Promotion of Science (JSPS), AMED under Grant Number JP21am0401026, and the Mochida Memorial Foundation for Medical and Pharmaceutical Research. Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",

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AU - Wang, Lei

AU - Okamura, Hidenori

AU - Sasaki, Shigeki

AU - Taniguchi, Yosuke

N1 - Funding Information: The present study was supported by Grants-in-Aid for Scientific Research (B) (Grant Number 19H03351 for Y. T. and 18H02558 for S. S.) from the Japan Society for the Promotion of Science (JSPS), AMED under Grant Number JP21am0401026, and the Mochida Memorial Foundation for Medical and Pharmaceutical Research. Publisher Copyright: © The Royal Society of Chemistry.

PY - 2020/8/28

Y1 - 2020/8/28

N2 - We recently found the translocation of double-stranded DNA into the nucleus. We herein describe the concept of novel booster oligodeoxynucleotides including 2′-deoxy uridine, which release antigene oligonucleotides in the nucleus by enzymatic digestion. This system exhibited stronger hTERT mRNA expression inhibitory activity than single-stranded antigene oligonucleotides.

AB - We recently found the translocation of double-stranded DNA into the nucleus. We herein describe the concept of novel booster oligodeoxynucleotides including 2′-deoxy uridine, which release antigene oligonucleotides in the nucleus by enzymatic digestion. This system exhibited stronger hTERT mRNA expression inhibitory activity than single-stranded antigene oligonucleotides.

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Enhancements in the utilization of antigene oligonucleotides in the nucleus by booster oligonucleotides

Abstract

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