Abstract
We recently found the translocation of double-stranded DNA into the nucleus. We herein describe the concept of novel booster oligodeoxynucleotides including 2′-deoxy uridine, which release antigene oligonucleotides in the nucleus by enzymatic digestion. This system exhibited stronger hTERT mRNA expression inhibitory activity than single-stranded antigene oligonucleotides.
Original language | English |
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Pages (from-to) | 9731-9734 |
Number of pages | 4 |
Journal | Chemical Communications |
Volume | 56 |
Issue number | 67 |
DOIs | |
Publication status | Published - 2020 Aug 28 |
Externally published | Yes |
ASJC Scopus subject areas
- Catalysis
- Electronic, Optical and Magnetic Materials
- Ceramics and Composites
- Chemistry(all)
- Surfaces, Coatings and Films
- Metals and Alloys
- Materials Chemistry