Enhancements in the utilization of antigene oligonucleotides in the nucleus by booster oligonucleotides

Lei Wang, Hidenori Okamura, Shigeki Sasaki, Yosuke Taniguchi

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

We recently found the translocation of double-stranded DNA into the nucleus. We herein describe the concept of novel booster oligodeoxynucleotides including 2′-deoxy uridine, which release antigene oligonucleotides in the nucleus by enzymatic digestion. This system exhibited stronger hTERT mRNA expression inhibitory activity than single-stranded antigene oligonucleotides.

Original languageEnglish
Pages (from-to)9731-9734
Number of pages4
JournalChemical Communications
Volume56
Issue number67
DOIs
Publication statusPublished - 2020 Aug 28
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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