Enhancement of the binding ability of a ligand for nucleobase recognition by introducing a methyl group

Qing Dai, Chun Yan Xu, Yusuke Sato, Keitaro Yoshimoto, Seiichi Nishizawa, Norio Teramae

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)

Abstract

The recognition ability of pteridine derivatives for nucleobases opposite an abasic (AP) site in an oligodeoxynucleotide (ODN) duplex is enhanced by using a propylene residue (Spacer-C3) as an AP site. The recognition ability is further enhanced both by attaching methyl groups to a fluorescent ligand and by measuring the fluorescence response at 5°C; 6.2 × 106 M-1 of the binding constant is attained between 2-amino-6,7-dimethyl- 4-hydroxypteridine and guanine opposite the AP site in water. 2006

Original languageEnglish
Pages (from-to)201-203
Number of pages3
Journalanalytical sciences
Volume22
Issue number2
DOIs
Publication statusPublished - 2006 Feb

ASJC Scopus subject areas

  • Analytical Chemistry

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