This paper reports the preparation of 14-mer triplex-forming oligonucleotides (TFOs) containing a 2-Omethyl- 1-β-phenyl-α-propargyl-ribose unit, which was conjugated with azide-modified molecules via a click reaction. Modification of these TFOs with pyrene assisted triplex formation, improving the stability of the triplex DNA and the anti-proliferative effects against A549 cells.
- Artificial nucleoside
- Triplex-forming oligonucleotide
ASJC Scopus subject areas
- Drug Discovery