Enhancement of NO production in activated in vivo by an antimalarial crude drug, Dichroa febrifuga

Kiyoshi Murata, Fumihide Takano, Shinji Fushiya, Yoshiteru Oshima

Research output: Contribution to journalArticlepeer-review

49 Citations (Scopus)

Abstract

The effect of an antimalarial crude drug, Dichroa febrifuga Lour. on nitric oxide (NO) production in bacillus Calmette Guerin-induced mouse peritoneal macrophages activated by lipopolysaccharide was investigated. The NO production was significantly enhanced by an oral administration of a MeOH extract of D. febrifuga. Febrifugine (1) was isolated as the main active compound, and the activation was dose-dependent in the dosage range of 0.1-1 mg/kg/day.

Original languageEnglish
Pages (from-to)729-733
Number of pages5
JournalJournal of Natural Products
Volume61
Issue number6
DOIs
Publication statusPublished - 1998 Jun 1

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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