Enhancement of NO production in activated in vivo by an antimalarial crude drug, Dichroa febrifuga

Kiyoshi Murata; Fumihide Takano; Shinji Fushiya; Yoshiteru Oshima

doi:10.1021/np970433o

Enhancement of NO production in activated in vivo by an antimalarial crude drug, Dichroa febrifuga

Kiyoshi Murata, Fumihide Takano, Shinji Fushiya, Yoshiteru Oshima

PHA - Molecular Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

53 Citations (Scopus)

Abstract

The effect of an antimalarial crude drug, Dichroa febrifuga Lour. on nitric oxide (NO) production in bacillus Calmette Guerin-induced mouse peritoneal macrophages activated by lipopolysaccharide was investigated. The NO production was significantly enhanced by an oral administration of a MeOH extract of D. febrifuga. Febrifugine (1) was isolated as the main active compound, and the activation was dose-dependent in the dosage range of 0.1-1 mg/kg/day.

Original language	English
Pages (from-to)	729-733
Number of pages	5
Journal	Journal of Natural Products
Volume	61
Issue number	6
DOIs	https://doi.org/10.1021/np970433o
Publication status	Published - 1998 Jun 1

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np970433o

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abstract = "The effect of an antimalarial crude drug, Dichroa febrifuga Lour. on nitric oxide (NO) production in bacillus Calmette Guerin-induced mouse peritoneal macrophages activated by lipopolysaccharide was investigated. The NO production was significantly enhanced by an oral administration of a MeOH extract of D. febrifuga. Febrifugine (1) was isolated as the main active compound, and the activation was dose-dependent in the dosage range of 0.1-1 mg/kg/day.",

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AU - Fushiya, Shinji

AU - Oshima, Yoshiteru

PY - 1998/6/1

Y1 - 1998/6/1

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AB - The effect of an antimalarial crude drug, Dichroa febrifuga Lour. on nitric oxide (NO) production in bacillus Calmette Guerin-induced mouse peritoneal macrophages activated by lipopolysaccharide was investigated. The NO production was significantly enhanced by an oral administration of a MeOH extract of D. febrifuga. Febrifugine (1) was isolated as the main active compound, and the activation was dose-dependent in the dosage range of 0.1-1 mg/kg/day.

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Enhancement of NO production in activated in vivo by an antimalarial crude drug, Dichroa febrifuga

Abstract

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