Enhancement of mRNA Synthesis from Marek's Disease Virus Genome in the Lymphoblas-toid Cell Line, MDCC-MSB1, by 5-Azacytidine

Masanobu Hayashi, Tatsuya Furuichi, Shaomin Ren, Shigeo Namioka, Emiko Isogai, Meihan Nonoyama

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Marek's disease virus (MDV) DNA in latently infected lymphoblastoid cell lines is considerably methylated. A treatment of the MDV-derived lymphoblastoid cell line, MDCC-MSB1 (MSB1), with 5-azacytidine (5-AzC) resulted in a hypomethylation of MDV DNA and an increase in mRNA from certain portions of the MDV DNA. These results suggest methylation of MDV DNA as being one of the factors associated with a repression of transcription of MDV DNA in the lymphoblastoid cell line, MSB1.

Original languageEnglish
Pages (from-to)305-308
Number of pages4
JournalJournal of Veterinary Medical Science
Volume56
Issue number2
DOIs
Publication statusPublished - 1994

Keywords

  • 5-AzC
  • MDV DNA
  • lymphoblastoid cell
  • mRNA synthesis
  • methylation

ASJC Scopus subject areas

  • veterinary(all)

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