Enhancement of in vitro gene transfection efficiency of adult stem cells by cationized polysaccharide derivatives

Jun Ichiro Jo, Masaya Yamamoto, Arimichi Okazaki, Tomonori Ikai, Yoshiaki Hirano, Yasuhiko Tabata

Research output: Contribution to conferencePaperpeer-review

5 Citations (Scopus)

Abstract

The technology to genetically manipulate adult stem cells has increasingly become important in terms of basic biological and medical researches on stem cells as well as cell therapy with genetically engineered cells. A non-viral gene carrier of polysaccharides with a cell specificity was explored by making use of sugar-recognition receptors on the cell surface for enhanced gene expression. Significantly higher gene expression by the polysaccharide carrier was achieved for bone marrow-derived stem cells than the LipofectAMINE™ commercially available.

Original languageEnglish
Pages2142
Number of pages1
Publication statusPublished - 2005
Externally publishedYes
Event54th SPSJ Annual Meeting 2005 - Yokohama, Japan
Duration: 2005 May 252005 May 27

Other

Other54th SPSJ Annual Meeting 2005
Country/TerritoryJapan
CityYokohama
Period05/5/2505/5/27

Keywords

  • Adult stem cells
  • Cationized polysaccharide derivatives
  • Gene transfection

ASJC Scopus subject areas

  • Engineering(all)

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