Abstract
6-O-Acyl derivatives of N-acetylmuramyl-l-alanyl-d-isoglutamine (MDP) and synthetic, low toxicity lipid-A analogues were examined for their ability to enhance the potency of current viral vaccines. 6-O-(2-Tetradecylhexadecanoyl)-MDP (B30-MDP) in non-irritative vehicles such as physiological saline, phosphate-buffered saline (PBS), squalene-PBS emulsion, Intralipid or liposomes, significantly stimulated the primary and secondary antibody production of guinea-pigs against influenza split or subunit vaccine and inactivated the hepatitis B virus surface (HBs) antigen. Mice seemed less responsive to the adjuvanticity of B30-MDP than guinea-pigs. Two low toxicity lipid A analogues, acylated β(1-6)-d-glucosamine disaccharide bisphosphates (which do not have amide-bound or ester-bound 3-acyloxyacyl groups unlike fully toxic Escherichia coli-type lipid A), caused significantly enhanced antibody responses, primary or secondary, when administered to mice by incorporation into liposomes with inactivated HBs antigen.
Original language | English |
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Pages (from-to) | 39-48 |
Number of pages | 10 |
Journal | Vaccine |
Volume | 7 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1989 Feb |
Keywords
- 6-O-acylmuramyldipeptide
- N-Acetylmuramyl-l-alanyl-d-isoglutamine
- hepatitis B virus vaccine
- influenza split vaccine
- influenza subunit vaccine
- low toxicity lipid-A analogues
- muramyldipeptide
ASJC Scopus subject areas
- Molecular Medicine
- Immunology and Microbiology(all)
- veterinary(all)
- Public Health, Environmental and Occupational Health
- Infectious Diseases