Enhancement of Dengue Virus Infection in Cultured Mouse Macrophages by Lipophilic Derivatives of Muramyl Peptides

Hak Hotta, Luis Fernando Sanchez, Morio Homma, Haruhiko Takada, Shozo Kotani

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Dengue virus multiplication in cultures of a murine myelomonocytic cell line (WEHI-3) as well as mouse peritoneal macrophages was enhanced by treatment of the cells with lipophilic derivatives of muramyl peptides for 2 or 3 days before virus inoculation, but not for 2 hr before virus inoculation or during the adsorption period. The infection-enhancing activity of the materials was dependent on their chemical structure, correlating with their immunoadjuvanticity. The infection enhancement in WEHI-3 cells was due primarily to an increase in the number of virus-infected cells which was accompanied by an increased cellular capacity to bind latex particles to their cell surfaces.

Original languageEnglish
Pages (from-to)533-541
Number of pages9
JournalMICROBIOLOGY and IMMUNOLOGY
Volume29
Issue number6
DOIs
Publication statusPublished - 1985 Jan 1

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Virology

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