Enhancement of Dengue Virus Infection in Cultured Mouse Macrophages by Lipophilic Derivatives of Muramyl Peptides

Hak Hotta; Luis Fernando Sanchez; Morio Homma; Haruhiko Takada; Shozo Kotani

doi:10.1111/j.1348-0421.1985.tb00855.x

Enhancement of Dengue Virus Infection in Cultured Mouse Macrophages by Lipophilic Derivatives of Muramyl Peptides

Hak Hotta, Luis Fernando Sanchez, Morio Homma, Haruhiko Takada, Shozo Kotani

DEN - Dental Sciences

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Dengue virus multiplication in cultures of a murine myelomonocytic cell line (WEHI-3) as well as mouse peritoneal macrophages was enhanced by treatment of the cells with lipophilic derivatives of muramyl peptides for 2 or 3 days before virus inoculation, but not for 2 hr before virus inoculation or during the adsorption period. The infection-enhancing activity of the materials was dependent on their chemical structure, correlating with their immunoadjuvanticity. The infection enhancement in WEHI-3 cells was due primarily to an increase in the number of virus-infected cells which was accompanied by an increased cellular capacity to bind latex particles to their cell surfaces.

Original language	English
Pages (from-to)	533-541
Number of pages	9
Journal	MICROBIOLOGY and IMMUNOLOGY
Volume	29
Issue number	6
DOIs	https://doi.org/10.1111/j.1348-0421.1985.tb00855.x
Publication status	Published - 1985 Jan 1

ASJC Scopus subject areas

Microbiology
Immunology
Virology

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10.1111/j.1348-0421.1985.tb00855.x

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title = "Enhancement of Dengue Virus Infection in Cultured Mouse Macrophages by Lipophilic Derivatives of Muramyl Peptides",

abstract = "Dengue virus multiplication in cultures of a murine myelomonocytic cell line (WEHI-3) as well as mouse peritoneal macrophages was enhanced by treatment of the cells with lipophilic derivatives of muramyl peptides for 2 or 3 days before virus inoculation, but not for 2 hr before virus inoculation or during the adsorption period. The infection-enhancing activity of the materials was dependent on their chemical structure, correlating with their immunoadjuvanticity. The infection enhancement in WEHI-3 cells was due primarily to an increase in the number of virus-infected cells which was accompanied by an increased cellular capacity to bind latex particles to their cell surfaces.",

author = "Hak Hotta and Sanchez, {Luis Fernando} and Morio Homma and Haruhiko Takada and Shozo Kotani",

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AU - Hotta, Hak

AU - Sanchez, Luis Fernando

AU - Homma, Morio

AU - Takada, Haruhiko

AU - Kotani, Shozo

PY - 1985/1/1

Y1 - 1985/1/1

N2 - Dengue virus multiplication in cultures of a murine myelomonocytic cell line (WEHI-3) as well as mouse peritoneal macrophages was enhanced by treatment of the cells with lipophilic derivatives of muramyl peptides for 2 or 3 days before virus inoculation, but not for 2 hr before virus inoculation or during the adsorption period. The infection-enhancing activity of the materials was dependent on their chemical structure, correlating with their immunoadjuvanticity. The infection enhancement in WEHI-3 cells was due primarily to an increase in the number of virus-infected cells which was accompanied by an increased cellular capacity to bind latex particles to their cell surfaces.

AB - Dengue virus multiplication in cultures of a murine myelomonocytic cell line (WEHI-3) as well as mouse peritoneal macrophages was enhanced by treatment of the cells with lipophilic derivatives of muramyl peptides for 2 or 3 days before virus inoculation, but not for 2 hr before virus inoculation or during the adsorption period. The infection-enhancing activity of the materials was dependent on their chemical structure, correlating with their immunoadjuvanticity. The infection enhancement in WEHI-3 cells was due primarily to an increase in the number of virus-infected cells which was accompanied by an increased cellular capacity to bind latex particles to their cell surfaces.

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