TY - JOUR
T1 - Enhancement of Dengue Virus Infection in Cultured Mouse Macrophages by Lipophilic Derivatives of Muramyl Peptides
AU - Hotta, Hak
AU - Sanchez, Luis Fernando
AU - Homma, Morio
AU - Takada, Haruhiko
AU - Kotani, Shozo
PY - 1985/1/1
Y1 - 1985/1/1
N2 - Dengue virus multiplication in cultures of a murine myelomonocytic cell line (WEHI-3) as well as mouse peritoneal macrophages was enhanced by treatment of the cells with lipophilic derivatives of muramyl peptides for 2 or 3 days before virus inoculation, but not for 2 hr before virus inoculation or during the adsorption period. The infection-enhancing activity of the materials was dependent on their chemical structure, correlating with their immunoadjuvanticity. The infection enhancement in WEHI-3 cells was due primarily to an increase in the number of virus-infected cells which was accompanied by an increased cellular capacity to bind latex particles to their cell surfaces.
AB - Dengue virus multiplication in cultures of a murine myelomonocytic cell line (WEHI-3) as well as mouse peritoneal macrophages was enhanced by treatment of the cells with lipophilic derivatives of muramyl peptides for 2 or 3 days before virus inoculation, but not for 2 hr before virus inoculation or during the adsorption period. The infection-enhancing activity of the materials was dependent on their chemical structure, correlating with their immunoadjuvanticity. The infection enhancement in WEHI-3 cells was due primarily to an increase in the number of virus-infected cells which was accompanied by an increased cellular capacity to bind latex particles to their cell surfaces.
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U2 - 10.1111/j.1348-0421.1985.tb00855.x
DO - 10.1111/j.1348-0421.1985.tb00855.x
M3 - Article
C2 - 4046890
AN - SCOPUS:0022260980
VL - 29
SP - 533
EP - 541
JO - Microbiology and Immunology
JF - Microbiology and Immunology
SN - 0385-5600
IS - 6
ER -
