Enhancement of cavitation inception by second-harmonic superimposition

Shin Yoshizawa, Ryo Takagi, Jun Yasuda, Shin ichiro Umemura

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)


High-intensity focused ultrasound (HIFU) treatment with cavitation bubbles has attracted much attention because they enhance the therapeutic efficacy of HIFU. Negative acoustic pressure is known toprimarily determine the cavitation threshold. However, it is hard to generate highly negative acoustic pressure over the cavitation threshold by ultrasonic focusing because of the nonlinear propagation. The sequence, starting with the second-harmonic superimposed pulse waves enhancing the peak negative pressure, and followed by those enhancing the peak positive pressure, demonstrated the highest efficiency in cavitation inception. A high speed camera showed that the negative-pressure enhanced pulse waves produced a small cloud of cavitated microbubbles at the first stage and that the positive-pressure enhanced pulse waves expanded the microbubble cloud at the second stage.

Original languageEnglish
Title of host publicationNonlinear Acoustics
Subtitle of host publicationState-of-the-Art and Perspectives, ISNA 2012 - 19th International Symposium on Nonlinear Acoustics
Number of pages4
Publication statusPublished - 2012 May 1

Publication series

NameAIP Conference Proceedings
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616


  • Acoustic cavitation
  • Cavitation cloud
  • HIFU

ASJC Scopus subject areas

  • Physics and Astronomy(all)


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