Enhanced Rho-kinase activity in patients with vasospastic angina after the Great East Japan Earthquake

Taro Nihei, Jun Takahashi, Yoku Kikuchi, Yusuke Takagi, Kiyotaka Hao, Ryuji Tsuburaya, Takashi Shiroto, Yoshitaka Ito, Yasuharu Matsumoto, Masaharu Nakayama, Kenta Ito, Satoshi Yasuda, Hiroaki Shimokawa

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Background: It remains unclear whether disease activity of vasospastic angina (VSA) is altered during a disaster. Methods and Results: Before and after the Great East Japan Earthquake, we examined Rho-kinase activity in circulating neutrophils of 11 VSA patients and their mental stress with the post-traumatic stress disorder (PTSD) questionnaire. Rho-kinase activity was significantly increased at 6 months after the Earthquake, and was returned to baseline level at 12 months. Importantly, percent change in Rho-kinase activity was significantly correlated with the PTSD score. Conclusions: These results indicate that the Rho-kinase activity of VSA patients was transiently enhanced associated with disaster-related mental stress.

Original languageEnglish
Pages (from-to)2892-2894
Number of pages3
JournalCirculation Journal
Volume76
Issue number12
DOIs
Publication statusPublished - 2012

Keywords

  • Angina
  • Stress
  • Vasospasm

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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