Enhanced growth of cultured fibroblasts by a synthetic polyanionic polymer

Tomohiro Sawa, Yukihisa Okumura, Junzo Sunamoto, Jian L. Ding, Raphael M. Ottenbrite

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


A synthetic polyanionic polymer, poly(maleic acid-alt-7,12-dioxaspiro-[5,6]dodec-9-ene), exhibits mitogen-like behavior for cultured fibroblasts. Cultures of L929 and STO fibroblasts in the presence of this polymer resulted in enhanced growth by both fibroblast cell lines. After three days, at optimum polymer concentrations, the cell numbers increased 3.7-fold for the STO cells and 1.9-fold for the L929 cells compared to the cells cultured in the same environment without the polymer. The polymer promoted this growth without any other external growth factors. This result suggests that the polymer has a direct effect on the growth of both of these fibroblast cells.

Original languageEnglish
Pages (from-to)17-27
Number of pages11
JournalJournal of Bioactive and Compatible Polymers
Issue number1
Publication statusPublished - 1996 Jan

ASJC Scopus subject areas

  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry


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