Engineering Niches for Cardiovascular Tissue Regeneration

Kay Maeda, Erik J. Suuronen, Marc Ruel

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The currently available therapeutic strategies for end-stage congestive heart failure are all invasive surgical approaches, including implantable devices and, ultimately, heart transplantation. However, these surgical treatments are unable to restore damaged tissue or provide functional restoration due to the limited intrinsic self-regenerative capacity of the highly organized cellular structure of the adult heart. Regenerative therapy based on stem cells holds promise as a treatment to overcome this limitation, but to-date has achieved only modest outcomes in clinical trials. To enhance potential stem cell behavior and exploit its maximum functional effect, numerous studies have taken great effort to elucidate the cardiac microenvironment and stem cell niches. Over the last decade, there has been impressive progress in the development of biomaterials that provide a suitable microenvironment for cells. Biomaterials can mimic the natural cardiac environment, providing important biophysical and biochemical cues to stimulate cell proliferation, differentiation, and their therapeutic effects, and to direct regeneration. Numerous biomaterial strategies have been developed to treat cardiac disease, with many promising outcomes for the clinical setting. This chapter describes the properties and function of biomaterials as stem cell niches in the cardiac repair process and their application in cardiac tissue engineering.

Original languageEnglish
Title of host publicationBiology and Engineering of Stem Cell Niches
PublisherElsevier Inc.
Pages459-478
Number of pages20
ISBN (Electronic)9780128027561
ISBN (Print)9780128027349
DOIs
Publication statusPublished - 2017 Apr 14
Externally publishedYes

Keywords

  • Biomaterials
  • Cardiac extracellular matrix
  • Cardiac stem/progenitor cells
  • Cardiomyocytes
  • Collagen
  • Heart failure
  • Myocardial infarction

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Maeda, K., Suuronen, E. J., & Ruel, M. (2017). Engineering Niches for Cardiovascular Tissue Regeneration. In Biology and Engineering of Stem Cell Niches (pp. 459-478). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-802734-9.00029-9