Engineering a Perfusable Vascular Network in a Microfluidic Device for a Morphological Analysis

Yuji Nashimoto, Yukako Teraoka, Yuichiro Arima, Sanshiro Hanada, Akiko Nakamasu, Hidetoshi Kotera, Koichi Nishiyama, Takashi Miura, Ryuji Yokokawa

Research output: Contribution to journalArticlepeer-review

Abstract

Luminal flow in a vascular network delivers nutrients and oxygen to cells in human bodies and applies mechanical stimuli to maintain vascular functions. Although many in vitro vascular models have been developed, there are no reports elucidating the effect of a long-term perfusion in a vascular network. Here, we report two types of microfluidic devices to investigate a vascular remodeling and long-term tissue culture in vitro. We observed formation of angiogenic spouts and a change of the volume of the vascularized tissue model in our microfluidic devices. Our method provides a new platform to study developmental biology with a long-term perfusion.

Original languageEnglish
Pages (from-to)275-280
Number of pages6
JournalIEEJ Transactions on Sensors and Micromachines
Volume138
Issue number7
DOIs
Publication statusPublished - 2018 Jan 1
Externally publishedYes

Keywords

  • Long-term perfusion
  • Microfluidic device
  • Morphogenesis
  • Tissue model
  • Vascular model
  • Vascular remodeling

ASJC Scopus subject areas

  • Mechanical Engineering
  • Electrical and Electronic Engineering

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