Engagement of NKG2D by cognate ligand or antibody alone is insufficient to mediate costimulation of human and mouse CD8+ T cells

Lauren I.Richie Ehrlich, Kouetsu Ogasawara, Jessica A. Hamerman, Rayna Takaki, Alessandra Zingoni, James P. Allison, Lewis L. Lanier

Research output: Contribution to journalArticlepeer-review

82 Citations (Scopus)

Abstract

CD8+ T cells require a signal through a costimulatory receptor in addition to TCR engagement to become activated. The role of CD28 in costimulating T cell activation is well established. NKG2D, a receptor found on NK cells, CD8+ αβ-TCR+ T cells, and γδ-TCR+ T cells, has also been implicated in T cell costimulation. In this study we have evaluated the role of NKG2D in costimulating mouse and human naive and effector CD8+ T cells. Unexpectedly, in contrast to CD28, NK62D engagement by ligand or mAb is not sufficient to costimulate naive or effector CD8+ T cell responses in conventional T cell populations. While NKG2D did not costimulate CD8+ T cells on its own, it was able to modify CD28-mediated costimulation of human CD8+ T cells under certain contitions. It is, therefore, likely that NKG2D acts as a costimulatory molecule only ander restricted conditions or requires additional cofactors.

Original languageEnglish
Pages (from-to)1922-1931
Number of pages10
JournalJournal of Immunology
Volume174
Issue number4
DOIs
Publication statusPublished - 2005 Feb 15

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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