Energy landscape of polymorphic amyloid generation of β2-microglobulin revealed by calorimetry

Misaki Kinoshita, Yuxi Lin, Itoh Dai, Masaki Okumura, Natalia Markova, John E. Ladbury, Fabio Sterpone, Young Ho Lee

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Understanding of amyloid aggregation in terms of thermodynamics and kinetics is still limited. We herein examined the mechanism of β2-microglobulin amyloidogenesis using our unique method of isothermal titration calorimetry-based thermodynamic/kinetic measurements, and revealed the energy landscape of polymorphic amyloidogenesis under biological environment-mimicking conditions including shear forces and crowding effects.

Original languageEnglish
Pages (from-to)7995-7998
Number of pages4
JournalChemical Communications
Volume54
Issue number57
DOIs
Publication statusPublished - 2018 Jan 1

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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    Kinoshita, M., Lin, Y., Dai, I., Okumura, M., Markova, N., Ladbury, J. E., Sterpone, F., & Lee, Y. H. (2018). Energy landscape of polymorphic amyloid generation of β2-microglobulin revealed by calorimetry. Chemical Communications, 54(57), 7995-7998. https://doi.org/10.1039/c8cc02718h