Endovascular Therapy Outcomes and Intravascular Ultrasound Findings in Thromboangiitis Obliterans (Buerger's Disease)

Osami Kawarada, Teruyoshi Kume, Shinobu Ayabe, Takako Nakaya, Michikazu Nakai, Kunihiro Nishimura, Teruo Noguchi, Yoshiaki Yokoi, Hisao Ogawa, Satoshi Yasuda

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


Purpose: To investigate outcomes of contemporary endovascular therapy and intravascular ultrasound (IVUS) findings in thromboangiitis obliterans (TAO) patients. Methods: Between April 2007 and January 2016, 20 patients (mean age 45±8 years; 16 men) underwent endovascular therapy for TAO-related lesions in 25 consecutive limbs. Subjects exhibited a broad array of clinical symptoms, including critical limb ischemia (n=15) and claudication (10) in the lower (n=20) and upper (n=5) limbs. Results: Procedure success was achieved in 24 (96%) limbs (complete success in 16 and partial success in 8), all of which exhibited improvements of at least 1 grade of the Rutherford category. Kaplan-Meier analysis showed that reintervention-free rates were 81.9% (95% CI 0.586 to 0.928) at 6 months and 71.7% at 10 months (95% CI 0.473 to 0.862). IVUS was performed in 20 limbs and revealed unique findings, including the "bull's-eye" appearance, "lotus-root" appearance, and "bunch of grapes" appearance. During a mean follow-up of 26±19 months, the limb salvage rate was 100% with no deaths. Conclusion: Contemporary endovascular therapy might be able to serve as a potential option for TAO patients with lower and upper limb symptoms. Liberal application of IVUS could help us understand the pathology of TAO to support endovascular therapy for TAO.

Original languageEnglish
Pages (from-to)504-515
Number of pages12
JournalJournal of Endovascular Therapy
Issue number4
Publication statusPublished - 2017 Aug 1
Externally publishedYes


  • Buerger's disease
  • angioplasty
  • claudication
  • critical limb ischemia
  • intravascular ultrasound
  • peripheral artery disease
  • thromboangiitis obliterans

ASJC Scopus subject areas

  • Surgery
  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


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