Endotoxin Induces Severe Inflammatory Reactions with Necrosis at Sites Primed with Delayed-Type Hypersensitivity Reactions in Guinea Pigs

Shigeki Nagao, Yoshihiro Kawabata, Haruhiko Takada, Haruhiko Takada

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Guinea pigs immunized with Freund's complete adjuvant received challenge injection of the purified protein derivative of Mycobacterium tuberculosis in the flanks and the corneas to prepare delayed-type hypersensitivity (DTH) reactions. The animals were injected subcutaneously with lipopolysaccharide (LPS) or a synthetic lipid A (LA-15-PP). At the skin site primed with DTH reaction, increased swelling and hemorrhagic reaction followed by a definite necrotic reaction occurred. Severe corneal reactions were also observed in the animals. These findings indicate that bacterial endotoxin modulates DTH reactions and induces severe inflammatory reactions.

Original languageEnglish
Pages (from-to)1011-1014
Number of pages4
JournalMICROBIOLOGY and IMMUNOLOGY
Volume39
Issue number12
DOIs
Publication statusPublished - 1995 Jan 1

Keywords

  • Delayed-type hypersensitivity
  • Endotoxin
  • Inflammation
  • Necrosis

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Virology

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