TY - JOUR
T1 - Endothelium-derived relaxing factor and coronary vasospasm
AU - Vanhoutte, P. M.
AU - Shimokawa, H.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1989
Y1 - 1989
N2 - The endothelium releases the powerful vasodilator and antiaggregatory substance, EDRF, both under basal conditions and upon stimulation by a wide variety of agents. Endothelial injury or dysfunction may play an important role in the spasmogenicity of the coronary artery, although other possible alterations related to atherosclerosis should also be considered. Among the possible stimuli, aggregating platelets are important as a source of vasoconstrictor substances. The endothelium may also produce the vasoactive substances EDHF and EDCF(s). Their pathophysiologic significance remains to be determined.
AB - The endothelium releases the powerful vasodilator and antiaggregatory substance, EDRF, both under basal conditions and upon stimulation by a wide variety of agents. Endothelial injury or dysfunction may play an important role in the spasmogenicity of the coronary artery, although other possible alterations related to atherosclerosis should also be considered. Among the possible stimuli, aggregating platelets are important as a source of vasoconstrictor substances. The endothelium may also produce the vasoactive substances EDHF and EDCF(s). Their pathophysiologic significance remains to be determined.
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U2 - 10.1161/01.CIR.80.1.1
DO - 10.1161/01.CIR.80.1.1
M3 - Review article
C2 - 2661051
AN - SCOPUS:0024312198
VL - 80
SP - 1
EP - 9
JO - Circulation
JF - Circulation
SN - 0009-7322
IS - 1
ER -