Endothelium-derived relaxing factor and coronary vasospasm

P. M. Vanhoutte, H. Shimokawa

Research output: Contribution to journalReview articlepeer-review

281 Citations (Scopus)


The endothelium releases the powerful vasodilator and antiaggregatory substance, EDRF, both under basal conditions and upon stimulation by a wide variety of agents. Endothelial injury or dysfunction may play an important role in the spasmogenicity of the coronary artery, although other possible alterations related to atherosclerosis should also be considered. Among the possible stimuli, aggregating platelets are important as a source of vasoconstrictor substances. The endothelium may also produce the vasoactive substances EDHF and EDCF(s). Their pathophysiologic significance remains to be determined.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
Issue number1
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


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