Endothelium-derived relaxing factor and coronary vasospasm

P. M. Vanhoutte; H. Shimokawa

doi:10.1161/01.CIR.80.1.1

Endothelium-derived relaxing factor and coronary vasospasm

P. M. Vanhoutte, H. Shimokawa

MED - Medical Sciences

Research output: Contribution to journal › Review article › peer-review

266 Citations (Scopus)

Abstract

The endothelium releases the powerful vasodilator and antiaggregatory substance, EDRF, both under basal conditions and upon stimulation by a wide variety of agents. Endothelial injury or dysfunction may play an important role in the spasmogenicity of the coronary artery, although other possible alterations related to atherosclerosis should also be considered. Among the possible stimuli, aggregating platelets are important as a source of vasoconstrictor substances. The endothelium may also produce the vasoactive substances EDHF and EDCF(s). Their pathophysiologic significance remains to be determined.

Original language	English
Pages (from-to)	1-9
Number of pages	9
Journal	Circulation
Volume	80
Issue number	1
DOIs	https://doi.org/10.1161/01.CIR.80.1.1
Publication status	Published - 1989

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Physiology (medical)

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AB - The endothelium releases the powerful vasodilator and antiaggregatory substance, EDRF, both under basal conditions and upon stimulation by a wide variety of agents. Endothelial injury or dysfunction may play an important role in the spasmogenicity of the coronary artery, although other possible alterations related to atherosclerosis should also be considered. Among the possible stimuli, aggregating platelets are important as a source of vasoconstrictor substances. The endothelium may also produce the vasoactive substances EDHF and EDCF(s). Their pathophysiologic significance remains to be determined.

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