Endothelin in ectopic ACTH-secreting bronchial carcinoid tumors

K. Takahashi, F. Satoh, O. Murakami, Kazuhito Totsune, M. Sone, K. Itoi, M. Ohneda, T. Mouri

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

The presence of immunoreactive endothelin (ir-ET) in the tumor tissues of two cases of ectopic ACTH-secreting bronchial carcinoid tumors was studied by radioimmunoassay. The cross-reaction with big ET-1, ET-2, and ET-3 was 5%, 6%, and 6%, respectively. Tumor tissue ir-ET concentrations in two ectopic ACTH-secreting bronchial carcinoid tumors were 920 and 3,370 fmol/g wet weight, which were much higher than those in pheochromocytomas (146 ± 70 fmol/g wet weight: n = 12, mean ± SD), adrenocortical tumors (115 ± 105 fmol/g wet weight, n = 14), and normal parts of adrenal glands (82 ± 31 fmol/g wet weight, n = 12). High-performance liquid chromatography of the tumor tissue extract showed that the ir-ET was mainly eluted in the position of ET-1. Plasma levels of ir-ET in these two cases were not elevated (1.2 and 1.7 pmol/L). The findings of the present study suggest that ET-1 has local pathophysiologic roles in the tumor tissues of ectopic ACTH-secreting bronchial carcinoid tumors.

Original languageEnglish
Pages (from-to)S288-S290
JournalJournal of Cardiovascular Pharmacology
Volume22
Issue numberSUPPL. 8
Publication statusPublished - 1993 Dec 1

Keywords

  • ACTH
  • Adrenal
  • Carcinoid
  • Ectopic
  • Endothelin
  • Radioimmunoassay
  • Tumor

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

Fingerprint

Dive into the research topics of 'Endothelin in ectopic ACTH-secreting bronchial carcinoid tumors'. Together they form a unique fingerprint.

Cite this