TY - JOUR
T1 - Endogenous virus genomes become hypomethylated tissue-Specifically during aging process of C57BL mice
AU - Ono, Tetsuya
AU - Shinya, Kayoko
AU - Uehara, Yoshihiko
AU - Okada, Shigefumi
N1 - Funding Information:
We thank Drs. T. Yagi for his assistancein computer analysis of the DNA sequence, and E. Buetti and H. Diggelmann for giving us the clone H. The work was partly supported by a Grant-in-aid for General Scientific Research from the Japanese Ministry of Education, Science, and Culture.
PY - 1989/10
Y1 - 1989/10
N2 - In an attempt to find out a cause for age-dependent derepression of endogenous viruses, extents of DNA methylation at the endogenous B- and C-type ecotropic viruses in brain, liver and spleen of C57BL/6NJcl were examined at three ages, newborn, young adult and old. Both endogenous viruses showed a slight but significant tissue-specific either hypo- or hypermethylation during post-natal developmental phase in three tissues. After maturation, however, no such change was detectable at most of the sites examined. The exceptions were C-type ecotropic virus in brain and B-type virus in spleen, where the age-dependent decreases of methylation were observed. The changes seemed to be continuations of preceding developmental hypomethylation. They indicated that the hypomethylation could be one of the causes for the age-dependent derepression of endogenous virus. It was further suggested that a mechanism to stop the developmental changes of DNA methylation at the maturation of individuals would be important in considering the reasons for the changes in senescent phase.
AB - In an attempt to find out a cause for age-dependent derepression of endogenous viruses, extents of DNA methylation at the endogenous B- and C-type ecotropic viruses in brain, liver and spleen of C57BL/6NJcl were examined at three ages, newborn, young adult and old. Both endogenous viruses showed a slight but significant tissue-specific either hypo- or hypermethylation during post-natal developmental phase in three tissues. After maturation, however, no such change was detectable at most of the sites examined. The exceptions were C-type ecotropic virus in brain and B-type virus in spleen, where the age-dependent decreases of methylation were observed. The changes seemed to be continuations of preceding developmental hypomethylation. They indicated that the hypomethylation could be one of the causes for the age-dependent derepression of endogenous virus. It was further suggested that a mechanism to stop the developmental changes of DNA methylation at the maturation of individuals would be important in considering the reasons for the changes in senescent phase.
KW - Aging
KW - Akv
KW - DNA methylation
KW - Mouse
KW - Mouse mammary tumor virus
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U2 - 10.1016/0047-6374(89)90056-0
DO - 10.1016/0047-6374(89)90056-0
M3 - Article
C2 - 2561001
AN - SCOPUS:0024342545
VL - 50
SP - 27
EP - 36
JO - Mechanisms of Ageing and Development
JF - Mechanisms of Ageing and Development
SN - 0047-6374
IS - 1
ER -