Endogenous virus genomes become hypomethylated tissue-Specifically during aging process of C57BL mice

Tetsuya Ono, Kayoko Shinya, Yoshihiko Uehara, Shigefumi Okada

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

In an attempt to find out a cause for age-dependent derepression of endogenous viruses, extents of DNA methylation at the endogenous B- and C-type ecotropic viruses in brain, liver and spleen of C57BL/6NJcl were examined at three ages, newborn, young adult and old. Both endogenous viruses showed a slight but significant tissue-specific either hypo- or hypermethylation during post-natal developmental phase in three tissues. After maturation, however, no such change was detectable at most of the sites examined. The exceptions were C-type ecotropic virus in brain and B-type virus in spleen, where the age-dependent decreases of methylation were observed. The changes seemed to be continuations of preceding developmental hypomethylation. They indicated that the hypomethylation could be one of the causes for the age-dependent derepression of endogenous virus. It was further suggested that a mechanism to stop the developmental changes of DNA methylation at the maturation of individuals would be important in considering the reasons for the changes in senescent phase.

Original languageEnglish
Pages (from-to)27-36
Number of pages10
JournalMechanisms of Ageing and Development
Volume50
Issue number1
DOIs
Publication statusPublished - 1989 Oct

Keywords

  • Aging
  • Akv
  • DNA methylation
  • Mouse
  • Mouse mammary tumor virus

ASJC Scopus subject areas

  • Ageing
  • Developmental Biology

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