Enantioselective total synthesis of the potent Anti-HIV nucleoside EFdA

Masayuki Kageyama, Tomohiro Nagasawa, Mayumi Yoshida, Hiroshi Ohrui, Shigefumi Kuwahara

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)


A concise enantioselective total synthesis of 4′-ethynyl-2-fluoro- 2′-deoxyadenosine (EFdA), an extremely potent anti-HIV agent, has been accomplished from (R)-glyceraldehyde acetonide in 18% overall yield by a 12-step sequence involving a highly diastereoselective ethynylation of an α-alkoxy ketone intermediate

Original languageEnglish
Pages (from-to)5264-5266
Number of pages3
JournalOrganic letters
Issue number19
Publication statusPublished - 2011 Oct 7

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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