Abstract
The enantioselective total synthesis of idesolide has been accomplished in 20% overall yield from a known allylic alcohol by a nine-step sequence involving the Sharpless asymmetric epoxidation as the source of chirality and an efficient NaHCO3-promoted dimerization of the monomeric form of idesolide as the key transformation.
Original language | English |
---|---|
Pages (from-to) | 4965-4969 |
Number of pages | 5 |
Journal | Tetrahedron |
Volume | 66 |
Issue number | 27-28 |
DOIs | |
Publication status | Published - 2010 Jul 3 |
Keywords
- Antiinflammatory
- Dimerization
- Idesolide
- Spiro compounds
- Total synthesis
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry