Enantioselective total synthesis of enokipodins A-D

Shigefumi Kuwahara, Mana Saito

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

The first enantioselective total synthesis of enokipodins A-D, highly oxidized α-cuparenone-type sesquiterpenoids with antimicrobial activity, was accomplished by using Meyers' diastereoselective alkylation protocol for the construction of the C7-quaternary asymmetric center. The present synthesis also constitutes a formal enantioselective synthesis of (S)-1,4-cuparenediol and (S)-cuparene-1,4-quinone.

Original languageEnglish
Pages (from-to)5047-5049
Number of pages3
JournalTetrahedron Letters
Volume45
Issue number26
DOIs
Publication statusPublished - 2004 Jun 21

Keywords

  • Antibiotics
  • Cuparene
  • Enokipodin
  • Terpenoids

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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