Enantioselective total synthesis of enokipodins A-D

Shigefumi Kuwahara, Mana Saito

    Research output: Contribution to journalArticlepeer-review

    30 Citations (Scopus)


    The first enantioselective total synthesis of enokipodins A-D, highly oxidized α-cuparenone-type sesquiterpenoids with antimicrobial activity, was accomplished by using Meyers' diastereoselective alkylation protocol for the construction of the C7-quaternary asymmetric center. The present synthesis also constitutes a formal enantioselective synthesis of (S)-1,4-cuparenediol and (S)-cuparene-1,4-quinone.

    Original languageEnglish
    Pages (from-to)5047-5049
    Number of pages3
    JournalTetrahedron Letters
    Issue number26
    Publication statusPublished - 2004 Jun 21


    • Antibiotics
    • Cuparene
    • Enokipodin
    • Terpenoids

    ASJC Scopus subject areas

    • Biochemistry
    • Drug Discovery
    • Organic Chemistry


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