Enantioselective total synthesis of aspergillide C

Tomohiro Nagasawa, Shigefumi Kuwahara

Research output: Contribution to journalArticlepeer-review

53 Citations (Scopus)


(Chemical Equation Presented) The first enantioselective total synthesis of aspergillide C, a cytotoxic 14-membered macrotide isolated from the marine-derived fungus Aspergillus ostianus, has been accomplished from a commercially available chiral glycidol derivative by a 12-step sequence involving an expeditious preparation of a cyclic acetal intermediate and a trans-selective Ferrier-type two-carbon homologation reaction.

Original languageEnglish
Pages (from-to)761-764
Number of pages4
JournalOrganic letters
Issue number3
Publication statusPublished - 2009 Feb 5

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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