Enantioselective total synthesis of aspergillide C

Tomohiro Nagasawa, Shigefumi Kuwahara

    Research output: Contribution to journalArticlepeer-review

    56 Citations (Scopus)


    (Chemical Equation Presented) The first enantioselective total synthesis of aspergillide C, a cytotoxic 14-membered macrotide isolated from the marine-derived fungus Aspergillus ostianus, has been accomplished from a commercially available chiral glycidol derivative by a 12-step sequence involving an expeditious preparation of a cyclic acetal intermediate and a trans-selective Ferrier-type two-carbon homologation reaction.

    Original languageEnglish
    Pages (from-to)761-764
    Number of pages4
    JournalOrganic letters
    Issue number3
    Publication statusPublished - 2009 Feb 5

    ASJC Scopus subject areas

    • Biochemistry
    • Physical and Theoretical Chemistry
    • Organic Chemistry


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