Enantioselective total synthesis of antiangeogenic pentaketide dimers, epoxyquinols A and B, through an asymmetric aldol approach to their common monomeric precursor

Shigefumi Kuwahara, Sunao Imada

    Research output: Contribution to journalArticlepeer-review

    27 Citations (Scopus)

    Abstract

    A new enantioselective total synthesis of epoxyquinols A and B possessing unique pentaketide dimeric structures and potent antiangeogenic activity was achieved by oxidative dimerization of a monomeric pentaketide precursor obtained by the Evans asymmetric aldol reaction and a series of operationally simple transformations.

    Original languageEnglish
    Pages (from-to)547-549
    Number of pages3
    JournalTetrahedron Letters
    Volume46
    Issue number4
    DOIs
    Publication statusPublished - 2005 Jan 24

    Keywords

    • Angeogenesis
    • Asymmetric aldol reaction
    • Epoxyquinol
    • Polyketide

    ASJC Scopus subject areas

    • Biochemistry
    • Drug Discovery
    • Organic Chemistry

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