@article{e71ec4ecaa724c08a4fc0a348c5fdc0c,
title = "Enantioselective total synthesis of antiangeogenic pentaketide dimers, epoxyquinols A and B, through an asymmetric aldol approach to their common monomeric precursor",
abstract = "A new enantioselective total synthesis of epoxyquinols A and B possessing unique pentaketide dimeric structures and potent antiangeogenic activity was achieved by oxidative dimerization of a monomeric pentaketide precursor obtained by the Evans asymmetric aldol reaction and a series of operationally simple transformations.",
keywords = "Angeogenesis, Asymmetric aldol reaction, Epoxyquinol, Polyketide",
author = "Shigefumi Kuwahara and Sunao Imada",
note = "Funding Information: We are grateful to Drs. Osada and Kakeya (RIKEN) for providing the copies of the spectra of natural epoxyquinols A and B. We also thank Drs. Hayashi and Shoji (The Tokyo University of Science) for sending the copy of the 1 H NMR spectrum of intermediate 4 . This work was supported, in part, by a Grant-in-Aid for Scientific Research (B) from the Ministry of Education, Culture, Sports, Science and Technology of Japan (No. 16380075). ",
year = "2005",
month = jan,
day = "24",
doi = "10.1016/j.tetlet.2004.12.001",
language = "English",
volume = "46",
pages = "547--549",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Limited",
number = "4",
}