Enantioselective total synthesis of antiangeogenic pentaketide dimers, epoxyquinols A and B, through an asymmetric aldol approach to their common monomeric precursor

Shigefumi Kuwahara; Sunao Imada

doi:10.1016/j.tetlet.2004.12.001

Enantioselective total synthesis of antiangeogenic pentaketide dimers, epoxyquinols A and B, through an asymmetric aldol approach to their common monomeric precursor

Shigefumi Kuwahara, Sunao Imada

AGR - Bioscience and Biotechnology for Future Bioindustries

Research output: Contribution to journal › Article

26 Citations (Scopus)

Abstract

A new enantioselective total synthesis of epoxyquinols A and B possessing unique pentaketide dimeric structures and potent antiangeogenic activity was achieved by oxidative dimerization of a monomeric pentaketide precursor obtained by the Evans asymmetric aldol reaction and a series of operationally simple transformations.

Original language	English
Pages (from-to)	547-549
Number of pages	3
Journal	Tetrahedron Letters
Volume	46
Issue number	4
DOIs	https://doi.org/10.1016/j.tetlet.2004.12.001
Publication status	Published - 2005 Jan 24

Keywords

Angeogenesis
Asymmetric aldol reaction
Epoxyquinol
Polyketide

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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Kuwahara, S., & Imada, S. (2005). Enantioselective total synthesis of antiangeogenic pentaketide dimers, epoxyquinols A and B, through an asymmetric aldol approach to their common monomeric precursor. Tetrahedron Letters, 46(4), 547-549. https://doi.org/10.1016/j.tetlet.2004.12.001

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