Enantioselective total synthesis of antiangeogenic pentaketide dimers, epoxyquinols A and B, through an asymmetric aldol approach to their common monomeric precursor

Shigefumi Kuwahara, Sunao Imada

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

A new enantioselective total synthesis of epoxyquinols A and B possessing unique pentaketide dimeric structures and potent antiangeogenic activity was achieved by oxidative dimerization of a monomeric pentaketide precursor obtained by the Evans asymmetric aldol reaction and a series of operationally simple transformations.

Original languageEnglish
Pages (from-to)547-549
Number of pages3
JournalTetrahedron Letters
Volume46
Issue number4
DOIs
Publication statusPublished - 2005 Jan 24

Keywords

  • Angeogenesis
  • Asymmetric aldol reaction
  • Epoxyquinol
  • Polyketide

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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