Enantioselective synthesis of substituted 3-quinolyl alkanols and their application to asymmetric autocatalysis

Itaru Sato, Tomohiko Nakao, Rie Sugie, Tsuneomi Kawasaki, Kenso Soai

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Enantioenriched 3-quinolyl alkanols act as asymmetric autocatalysts in the addition of diisopropylzinc to the corresponding substituted quinoline-3-carbaldehydes, to afford themselves with an amplified enantiomeric excess (ee) of up to 97%.

Original languageEnglish
Pages (from-to)1419-1428
Number of pages10
JournalSynthesis
Issue number9
DOIs
Publication statusPublished - 2004 Jun 18

Keywords

  • Asymmetric amplification
  • Asymmetric catalysis
  • Autocatalysis
  • Chirality
  • Quinoline

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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