Abstract
The first enantioselective synthesis of rumphellaone A, a cytotoxic 4,5-seco-caryophyllane derivative incorporating a γ-lactone ring as its structural feature, has been achieved by using base-induced intramolecular cyclization of an epoxy nitrile intermediate to install its cyclobutane skeleton as well as three contiguous stereocenters as the key transformation.
Original language | English |
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Pages (from-to) | 705-706 |
Number of pages | 2 |
Journal | Tetrahedron Letters |
Volume | 53 |
Issue number | 6 |
DOIs | |
Publication status | Published - 2012 Feb 8 |
Keywords
- Caryophyllane
- Cytotoxic
- Epoxy nitrile cyclization
- Rumphellaone A
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry