Enantioselective synthesis of phyllanthurinolactone, a leaf-closing substance of Phyllanthus urinaria L., and its analogs toward the development of molecular probes

Yoshifumi Urakawa, Takanori Sugimoto, Hirotaka Sato, Minoru Ueda

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

We report enantioselective synthesis of phyllanthurinolactone (1), a leaf-closing substance of Phyllanthus urinaria L., and its analogs with sugars other than D-glucose. Structure-activity relationship study using them revealed that the structure of the sugar moiety did not affect their bioactivity at all. This result is very important for the development of molecular probes based on the structure of 1.

Original languageEnglish
Pages (from-to)5885-5888
Number of pages4
JournalTetrahedron Letters
Volume45
Issue number30
DOIs
Publication statusPublished - 2004 Jul 19

Keywords

  • Bioactive substance
  • Nyctinasty
  • Plant

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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