Abstract
We report enantioselective synthesis of phyllanthurinolactone (1), a leaf-closing substance of Phyllanthus urinaria L., and its analogs with sugars other than D-glucose. Structure-activity relationship study using them revealed that the structure of the sugar moiety did not affect their bioactivity at all. This result is very important for the development of molecular probes based on the structure of 1.
Original language | English |
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Pages (from-to) | 5885-5888 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 45 |
Issue number | 30 |
DOIs | |
Publication status | Published - 2004 Jul 19 |
Keywords
- Bioactive substance
- Nyctinasty
- Plant
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry