Enantioselective synthesis of phyllanthurinolactone, a leaf-closing substance of Phyllanthus urinaria L., and its analogs toward the development of molecular probes

Yoshifumi Urakawa; Takanori Sugimoto; Hirotaka Sato; Minoru Ueda

doi:10.1016/j.tetlet.2004.05.129

Enantioselective synthesis of phyllanthurinolactone, a leaf-closing substance of Phyllanthus urinaria L., and its analogs toward the development of molecular probes

Yoshifumi Urakawa, Takanori Sugimoto, Hirotaka Sato, Minoru Ueda

SCI - Chemistry

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

We report enantioselective synthesis of phyllanthurinolactone (1), a leaf-closing substance of Phyllanthus urinaria L., and its analogs with sugars other than D-glucose. Structure-activity relationship study using them revealed that the structure of the sugar moiety did not affect their bioactivity at all. This result is very important for the development of molecular probes based on the structure of 1.

Original language	English
Pages (from-to)	5885-5888
Number of pages	4
Journal	Tetrahedron Letters
Volume	45
Issue number	30
DOIs	https://doi.org/10.1016/j.tetlet.2004.05.129
Publication status	Published - 2004 Jul 19

Keywords

Bioactive substance
Nyctinasty
Plant

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2004.05.129

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Enantioselective synthesis of phyllanthurinolactone, a leaf-closing substance of Phyllanthus urinaria L., and its analogs toward the development of molecular probes. / Urakawa, Yoshifumi; Sugimoto, Takanori; Sato, Hirotaka; Ueda, Minoru.

In: Tetrahedron Letters, Vol. 45, No. 30, 19.07.2004, p. 5885-5888.

Research output: Contribution to journal › Article › peer-review

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abstract = "We report enantioselective synthesis of phyllanthurinolactone (1), a leaf-closing substance of Phyllanthus urinaria L., and its analogs with sugars other than D-glucose. Structure-activity relationship study using them revealed that the structure of the sugar moiety did not affect their bioactivity at all. This result is very important for the development of molecular probes based on the structure of 1.",

keywords = "Bioactive substance, Nyctinasty, Plant",

author = "Yoshifumi Urakawa and Takanori Sugimoto and Hirotaka Sato and Minoru Ueda",

note = "Funding Information: This work was supported by the Ministry of Education, Science, Sports and Culture (Japan) Grant-in-Aid for Scientific Research (No 15681013) and JSPS Grant for T.S. This work was also supported by Grant-in-Aid for the 21st Century COE program of Tohoku University from the Ministry of Education, Culture, Sports, Science, and Technology, Japan.",

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AU - Urakawa, Yoshifumi

AU - Sugimoto, Takanori

AU - Sato, Hirotaka

AU - Ueda, Minoru

N1 - Funding Information: This work was supported by the Ministry of Education, Science, Sports and Culture (Japan) Grant-in-Aid for Scientific Research (No 15681013) and JSPS Grant for T.S. This work was also supported by Grant-in-Aid for the 21st Century COE program of Tohoku University from the Ministry of Education, Culture, Sports, Science, and Technology, Japan.

PY - 2004/7/19

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N2 - We report enantioselective synthesis of phyllanthurinolactone (1), a leaf-closing substance of Phyllanthus urinaria L., and its analogs with sugars other than D-glucose. Structure-activity relationship study using them revealed that the structure of the sugar moiety did not affect their bioactivity at all. This result is very important for the development of molecular probes based on the structure of 1.

AB - We report enantioselective synthesis of phyllanthurinolactone (1), a leaf-closing substance of Phyllanthus urinaria L., and its analogs with sugars other than D-glucose. Structure-activity relationship study using them revealed that the structure of the sugar moiety did not affect their bioactivity at all. This result is very important for the development of molecular probes based on the structure of 1.

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KW - Nyctinasty

KW - Plant

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Enantioselective synthesis of phyllanthurinolactone, a leaf-closing substance of Phyllanthus urinaria L., and its analogs toward the development of molecular probes

Abstract

Keywords

ASJC Scopus subject areas

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