Abstract
The enantioselective synthesis of aspergillide B, a 14-membered macrocyclic cytotoxin, was achieved in a 49% yield via 7 steps from a synthetic intermediate of aspergillide C. The spectroscopic data and specific rotation value for the synthetic material matched those of natural aspergillide B.
Original language | English |
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Pages (from-to) | 1893-1894 |
Number of pages | 2 |
Journal | Bioscience, Biotechnology and Biochemistry |
Volume | 73 |
Issue number | 8 |
DOIs | |
Publication status | Published - 2009 |
Keywords
- Aspergillide
- Cytotoxic
- Enantioselective synthesis
- Macrolide
ASJC Scopus subject areas
- Biotechnology
- Analytical Chemistry
- Biochemistry
- Applied Microbiology and Biotechnology
- Molecular Biology
- Organic Chemistry