Enantioselective Synthesis of Aspergillide B

Tomohiro Nagasawa, Shigefumi Kuwahara

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

The enantioselective synthesis of aspergillide B, a 14-membered macrocyclic cytotoxin, was achieved in a 49% yield via 7 steps from a synthetic intermediate of aspergillide C. The spectroscopic data and specific rotation value for the synthetic material matched those of natural aspergillide B.

Original languageEnglish
Pages (from-to)1893-1894
Number of pages2
JournalBioscience, Biotechnology and Biochemistry
Volume73
Issue number8
DOIs
Publication statusPublished - 2009

Keywords

  • Aspergillide
  • Cytotoxic
  • Enantioselective synthesis
  • Macrolide

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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