Abstract
5-Pyrimidyl alkanol with up to 96% ee was formed using chiral organic-inorganic hybrid silsesquioxane in the enantioselective addition of diisopropylzinc to pyrimidine-5-carbaldehyde, in conjunction with asymmetric autocatalysis.
Original language | English |
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Pages (from-to) | 7939-7941 |
Number of pages | 3 |
Journal | Tetrahedron Letters |
Volume | 45 |
Issue number | 42 |
DOIs | |
Publication status | Published - 2004 Oct 11 |
Externally published | Yes |
Keywords
- Asymmetric autocatalysis
- Asymmetric induction
- Asymmetric synthesis
- Chiral hybrid silsesquioxane
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry