Enantioselective Redox-Neutral Coupling of Aldehydes and Alkenes by an Iron-Catalyzed "catch-Release" Tethering Approach

Jing Li, Alexander Preinfalk, Nuno Maulide

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

The reductive coupling of aldehydes and alkenes is an emerging technology that holds the potential to reinvent carbonyl addition chemistry. However, existing enantioselective methods are limited to form "branched" products. Herein, we present a directed enantio- and diastereoselective alkylation of aldehydes with simple olefins to selectively yield linear coupling products. This is achieved by redox-neutral remote functionalization, whereby a tethering "catch-release" strategy decisively solves the key problems of reactivity and selectivity.

Original languageEnglish
Pages (from-to)143-147
Number of pages5
JournalJournal of the American Chemical Society
Volume141
Issue number1
DOIs
Publication statusPublished - 2019 Jan 9
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

Fingerprint Dive into the research topics of 'Enantioselective Redox-Neutral Coupling of Aldehydes and Alkenes by an Iron-Catalyzed "catch-Release" Tethering Approach'. Together they form a unique fingerprint.

Cite this