Enantioselective intramolecular cyclization of alkynyl esters catalyzed by a chiral Brønsted base

Azusa Kondoh; Hoa Thi Quynh Tran; Kyoko Kimura; Masahiro Terada

doi:10.1039/c6cc01690a

Enantioselective intramolecular cyclization of alkynyl esters catalyzed by a chiral Brønsted base

Azusa Kondoh, Hoa Thi Quynh Tran, Kyoko Kimura, Masahiro Terada

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

An enantioselective intramolecular cyclization reaction of alkynyl esters was developed, which employs a Brønsted base catalyst generated in situ from a chiral Schiff base and t-BuOK. This reaction is a rare example of the enantioselective intramolecular addition of simple ester enolates to alkynes under Brønsted base catalysis.

Original language	English
Pages (from-to)	5726-5729
Number of pages	4
Journal	Chemical Communications
Volume	52
Issue number	33
DOIs	https://doi.org/10.1039/c6cc01690a
Publication status	Published - 2016 Apr 28

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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abstract = "An enantioselective intramolecular cyclization reaction of alkynyl esters was developed, which employs a Br{\o}nsted base catalyst generated in situ from a chiral Schiff base and t-BuOK. This reaction is a rare example of the enantioselective intramolecular addition of simple ester enolates to alkynes under Br{\o}nsted base catalysis.",

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AU - Terada, Masahiro

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