Enantioselective hydrogenation of itaconate using rhodium bihelicenol phosphite complex. Matched/mismatched phenomena between helical and axial chirality

Daisuke Nakano, Masahiko Yamaguchi

Research output: Contribution to journalArticlepeer-review

49 Citations (Scopus)

Abstract

Phosphites prepared from bihelicenol, menthol (or 1-phenylethanol), and PCl3 are effective ligands for the rhodium-catalyzed enantioselective hydrogenation of dimethyl itaconate. Stereochemistry of the helicene moiety plays an important role in the asymmetric induction, and matched/mismatched phenomena are observed between helical and axial chirality.

Original languageEnglish
Pages (from-to)4969-4971
Number of pages3
JournalTetrahedron Letters
Volume44
Issue number27
DOIs
Publication statusPublished - 2003 Jun 30

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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