Enantioselective Hetero-Diels-Alder reaction with glyoxylate catalyzed by chiral titanium complex: asymmetric synthesis of the lactone portion of mevinolin and compactin

Masahiro Terada, Koichi Mikami, Takeshi Nakai

Research output: Contribution to journalArticlepeer-review

88 Citations (Scopus)

Abstract

Asymmetric Diels-Alder reaction with methyl glyoxylate catalyzed by the chiral titanium complex 1 provides the dihydropyran carboxylate in high enantiomeric purity, which can be converted to the lactone portion of mevinolin or compactin.

Original languageEnglish
Pages (from-to)935-938
Number of pages4
JournalTetrahedron Letters
Volume32
Issue number7
DOIs
Publication statusPublished - 1991 Feb 11
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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