Enantioselective Friedel-Crafts reaction of electron-rich alkenes catalyzed by chiral Brønsted acid

Masahiro Terada, Keiichi Sorimachi

Research output: Contribution to journalArticlepeer-review

289 Citations (Scopus)

Abstract

We present the first enantioselective catalysis of the Friedel-Crafts reaction via activation of electron-rich multiple bonds by a chiral Brønsted acid. The reaction of various indole derivatives with a broad range of substituted enecarbamates affords the corresponding Friedel-Crafts products in high yield and enantioselectivity.

Original languageEnglish
Pages (from-to)292-293
Number of pages2
JournalJournal of the American Chemical Society
Volume129
Issue number2
DOIs
Publication statusPublished - 2007 Jan 17

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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